Taking a genetic test before choosing a weight loss plan has made all the difference for me. I lost 20 pounds last year when I found out that I am a Fat Trimmer. I store fat easily. I guess I was designed for winter hibernation. Anyway, the key to weight loss and wellness for me is to cut fat intake to 30% of my total daily calories, take Nutrilite CLA ( the only one I can recommend ) and exercise with intensity at least 3 preferably 4 times a week for 30 minutes. After the test results came back I chose a 90 day weight loss challenge with the Body Key Plan. It worked beautifully. For those of us who have slowing metabolisms this is a great way to go.
Also, here is a link to some current research on Genetics and Weight Loss: http://now.tufts.edu/articles/diet-fits-your-genes